Key result
Peak negative myocardial velocity gradient by tissue Doppler imaging was lower in the ventricular septum of HCM patients compared to controls.
Why the study?
Does peak negative myocardial velocity gradient derived from tissue Doppler imaging correlate with fatty acid metabolism disorders in patients with hypertrophic cardiomyopathy?
Case-Control (n=27)
Does peak negative myocardial velocity gradient derived from tissue Doppler imaging correlate with fatty acid metabolism disorders in patients with hypertrophic cardiomyopathy?
Peak negative myocardial velocity gradient derived from tissue Doppler imaging correlates with regional fatty acid metabolism disorders in patients with hypertrophic cardiomyopathy.
Answers are grounded in this paper and cite their sources.
May link diastolic dysfunction to fatty acid metabolism in HCM; hypothesis-generating, needs prospective trials before practice change.
BACKGROUND: Tissue Doppler imaging (TDI) has been utilized to evaluate left ventricular myocardial dysfunction in patients with hypertrophic cardiomyopathy (HCM); however, no clear explanation for the abnormality of TDI variables has been forthcoming. HYPOTHESIS: Peak negative myocardial velocity gradient (MVG) derived from TDI may correlate with a disorder of fatty acid metabolism in patients with HCM. METHODS: Tissue Doppler imaging and 123I-beta-methyl iodophenyl pentadecanoic acid (123I-BMIPP) myocardial scintigraphy were performed in 15 patients with asymmetric septal hypertrophy (mean age 47 +/- 18 years) and in 12 healthy controls (mean age 43 +/- 10 years). RESULTS: In early 123I-BMIPP images, accumulation defects were observed in the ventricular septum in 12 patients and in the posterior wall in 8 patients with HCM. Peak negative MVG in the ventricular septum (1.1 +/- 0.5 vs. 2.8 +/- 0.5, p < 0.0001) and posterior wall (5.2 +/- 1.4 vs. 6.7 +/- 0.8, p < 0.01 ) was significantly lower in the HCM group than in the controls; also, these parameters were significantly lower in patients with than in those without a defect in the region in question. The peak negative MVG in the ventricular septum and posterior wall correlated inversely with the washout rate in all subjects. CONCLUSIONS: Peak negative MVG according to TDI is related to disorder of fatty acid metabolism in the regional left ventricular myocardium of patients with HCM.
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Yamada et al. (2004) conducted a case-control in Hypertrophic cardiomyopathy (n=27). Hypertrophic cardiomyopathy vs. Healthy controls was evaluated on Peak negative myocardial velocity gradient (MVG) in the ventricular septum (p=<0.0001). Peak negative myocardial velocity gradient by tissue Doppler imaging was lower in the ventricular septum of HCM patients compared to controls.
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