Key result
Transcatheter PFO closure did not significantly affect mean systolic flow velocity at the SVC-RA junction compared to normal controls (60 vs 64 cm/s; P=0.27).
Why the study?
The impact of bulky metallic patent foramen ovale occluder devices on normal blood flow at the superior vena cava-right atrial junction was not clear.
Does transcatheter PFO device closure alter superior vena cava-right atrial junction blood flow patterns compared to structurally normal hearts?
Case-Control (n=42)
Does transcatheter PFO device closure alter superior vena cava-right atrial junction blood flow patterns compared to structurally normal hearts?
Absolute Event Rate: 60% vs 64%
p-value: p=0.27
Transcatheter PFO closure does not significantly alter normal blood flow patterns at the superior vena cava-right atrial junction.
Preserved SVC-RA flow after PFO closure; leaves open hemodynamic effects in larger prospective cohorts.
BACKGROUND: The patent foramen ovale (PFO) occluder is a bulky metallic device. Its impact on the normal blood flow at the superior vena cava-right atrial (SVC-RA) junction is not clear. METHODS: We examined SVC-RA junction flow-pattern using pulsed-wave (PW) ultrasound Doppler in 21 patients (4 male, aged 52.7 ± 9 years) who underwent PFO device closure 4-120 months previously, in comparison with 21 age- and sex-matched controls (4 male, aged 51 ± 8.5 years) with structurally normal hearts. RESULTS: Mean systolic flow velocity at the SVC-RA junction was 60 ± 11 cm/s in the PFO closure group and 64 ± 17 cm/s in the control group (P = 0.27). Mean diastolic blood flow velocity at the SVC-RA junction in those groups was 30 ± 8 and 35 ± 9 cm/s, respectively (P = 0.1).The mean systolic wave duration was 439 ± 52 ms in the PFO closure group and 422 ± 67 ms in the control group (P = 0.4). The mean diastolic wave duration was 320 ± 75 and 277 ± 88 ms, respectively (P = 0.12). CONCLUSION: The study results show that transcatheter PFO closure does not affect the normal blood flow at the SVC-RA junction.
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Yalonetsky et al. (2019) conducted a case-control in Patent foramen ovale (n=42). Transcatheter PFO device closure vs. Age- and sex-matched controls with structurally normal hearts was evaluated on Mean systolic flow velocity at the SVC-RA junction (p=0.27). Transcatheter PFO closure did not significantly affect mean systolic flow velocity at the SVC-RA junction compared to normal controls (60 vs 64 cm/s; P=0.27).
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