Key result
Elevated PPBP and DEFA1/DEFA3 expression is linked to coronary heart disease in hyperlipidemia.
Cross-Sectional
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BACKGROUND: Coronary heart disease (CHD) is an important complication of atherosclerosis. Biomarkers, which associate with CHD development, are potential to predict CHD risk. To determine whether genes showing altered expression in hyperlipidaemia (H) and coronary heart disease (CHD) patients compared with controls could be CHD risk biomarkers. METHODS: Control, H, and CHD groups represented atherosclerosis to CHD development. Gene profiling was investigated in peripheral blood mononuclear cells using DNA microarrays. Eight selected genes expressed only in H and CHD groups were validated by real-time quantitative reverse transcription PCR and plasma protein determination. RESULTS: α-defensin (DEFA1/DEFA3), pro-platelet basic protein (PPBP), and beta and alpha2 hemoglobin mRNA expression was significantly increased in H and CHD groups compared with controls, but only plasma PPBP and α-defensin proteins were correspondingly increased. CONCLUSION: PPBP and DEFA1/DEFA3 could be potential CHD biomarkers in Thai hyperlipidaemia patients.
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Maneerat et al. (2017) conducted a cross-sectional in Hyperlipidaemia and Coronary Heart Disease. Hyperlipidaemia and coronary heart disease vs. Controls was evaluated on PPBP and DEFA1/DEFA3 mRNA and plasma protein expression. PPBP and DEFA1/DEFA3 mRNA and plasma protein levels were significantly increased in Thai patients with hyperlipidaemia and coronary heart disease compared with controls.
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