March 10, 2008European Heart Journal
Risk factors for myocardial infarction in women and men: insights from the INTERHEART study
Why the study?
Do differences in modifiable risk factor distributions explain why women develop acute myocardial infarction later than men?
Population
27,098 participants (6,787 women) from 52 countries in the INTERHEART global case-control study.
Design
Case-control
Authors
Discussion
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Member takes
Implication
Higher modifiable risk factor burden in younger men largely explains earlier MI onset; supports targeted prevention but leaves open causal confirmation in prospective studies.
Structured PICO
Do differences in modifiable risk factor distributions explain why women develop acute myocardial infarction later than men?
P
Population
27,098 participants (6,787 women) from 52 countries in the INTERHEART global case-control study.
O
Outcome
First acute myocardial infarctionhard clinical
Nine modifiable risk factors explain >90% of the population attributable risk for acute MI in both sexes, and higher risk factor levels at younger ages in men largely explain their earlier onset of MI compared to women.
Cite This Study
Anand et al. (2008) studied this question.