Key result
Nine modifiable risk factors accounted for a population-attributable risk for acute MI of 93.1% in men ≤55 years and 96.5% in women ≤65 years, indicating most premature MI is preventable.
Case-Control (n=29,972)
Yes
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Nine modifiable risk factors account for over 90% of the population-attributable risk for premature acute myocardial infarction in both men and women globally, indicating that most premature MIs are preventable.
Cardiovascular disease is a global problem. To enable more effective prevention strategies for myocardial infarction (MI), the INTERHEART study looked for differences between countries, and between men and women, in risk factors for acute MI.1 It was a case–control study with 15 152 cases of acute MI and 14 820 controls from 262 centres from 52 countries. Information about nine risk factors was collected: smoking, self-reported hypertension and diabetes, measured waist/hip ratio, psychosocial factors, diet, physical activity, alcohol consumption, and measured apolipoprotein B/apolipoprotein A1 ratio.1 In their first report. the INTERHEART Investigators concluded that these nine risk factors accounted for most of the risk for acute MI in both sexes, at all ages, and in all regions.1 When all nine risk factors were included in the analysis, the population-attributable risk for men ≤55 years was 93.1% and for women ≤65 years was 96.5%, indicating that most premature MI is preventable.1
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Duncan J. Campbell (2008) conducted a case-control in Acute myocardial infarction (n=29,972). Nine cardiovascular risk factors vs. Controls without acute MI was evaluated on Population-attributable risk for acute MI. Nine modifiable risk factors accounted for a population-attributable risk for acute MI of 93.1% in men ≤55 years and 96.5% in women ≤65 years, indicating most premature MI is preventable.
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