Key result
Children with a first episode of idiopathic nephrotic syndrome had significantly higher plasma Endothelin 1 levels compared to healthy controls (median 18.72 vs 11.16 pg/ml, p<0.001).
Why the study?
Are Endothelin 1 levels elevated in children with first episode of nephrotic syndrome compared to healthy controls?
Observational (n=50)
No
Are Endothelin 1 levels elevated in children with first episode of nephrotic syndrome compared to healthy controls?
Absolute Event Rate: 18.72% vs 11.16%
p-value: p=<0.001
Children with idiopathic nephrotic syndrome exhibit elevated Endothelin 1 levels indicating endothelial dysfunction, which improves following drug-induced remission.
Elevated endothelin-1 may indicate endothelial dysfunction risk in pediatric nephrotic syndrome; hypothesis-generating and leaves open prognostic or therapeutic utility.
Background: Endothelial dysfunction is the initial step for atherogenesis.Children with idiopathic nephrotic syndrome are at risk of endothelial dysfunction due to altered cholesterol metabolism which can lead to early atherosclerosis.Methods: In this analytical study with longitudinal follow up 25 children with first episode of nephrotic syndrome (FENS) aged 1e16 years along with 25 age and gender matched healthy controls were enrolled.Endothelin 1 (ET 1) levels were measured by ELISA (Cloud Clone Corp. and assembled by USCN Inc, U.S.A).Other variables were measured using standard biochemical methods.Primary outcome measure was plasma ET 1 level in children with FENS and in controls.Secondary outcome measure was to observe the levels of ET 1 in children with FENS at 12 weeks in remission.Results: The level of ET 1 was significantly higher (p < 0.001) in children with FENS as compared to controls.The level of ET 1 was significantly higher (p Z 0.006) in SSNS at the onset of nephrotic syndrome and was significantly lower (p Z 0.04) after 12 weeks of drug induced remission as compared to controls.SRNS children had higher levels of ET 1 than the steroid sensitive patients at onset but in was not statistically significant (p Z 0.062).ET 1 showed significant positive correlation with total
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Arumugam et al. (2017) conducted an observational in Idiopathic nephrotic syndrome (n=50). Idiopathic nephrotic syndrome vs. Healthy controls was evaluated on Plasma Endothelin 1 (ET 1) level at onset (p=<0.001). Children with a first episode of idiopathic nephrotic syndrome had significantly higher plasma Endothelin 1 levels compared to healthy controls (median 18.72 vs 11.16 pg/ml, p<0.001).
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