What is the clinical evidence from this study?

Study design: Cross-Sectional. Population: Coronary artery disease (n=50). Intervention: Doppler echocardiography vs. Invasive cardiac catheterization. Primary outcome: Correlation between noninvasive estimated PCWP and invasive catheter-derived PCWP (r=0.678, p=0.001).

What question did this study set out to answer?

The study aimed to correlate pulmonary capillary wedge pressure estimated by Doppler echocardiography with invasive measurements from cardiac catheterization.

January 1, 1970Cardiovascular JournalOpen Access

Noninvasive Estimation of PCWP with Doppler Transmitral Flow Velocity Pattern in Patients with Coronary Artery Disease

View Full Paper

Ask AI

Bookmark

Key result

Noninvasive estimation of pulmonary capillary wedge pressure using a Doppler echocardiography-derived equation incorporating mitral flow variables significantly correlated with invasive catheterization measurements (r=0.678).

Why the study?

Does Doppler echocardiography accurately estimate pulmonary capillary wedge pressure compared to invasive cardiac catheterization in patients with coronary artery disease?

Population

Patients with coronary artery disease undergoing simultaneous cardiac catheterization and Doppler…

Comparison

Doppler echocardiography vs Invasive cardiac catheterization

Design

Cross-sectional

Authors

RTRJ TamannaBangladesh Livestock Research Institute RJRaidah JahanDhaka Shishu Hospital AAAK AkandaNational Institute of Cardiovascular Diseases

Discussion

Member takes

Implication

May support noninvasive PCWP assessment; leaves open validation before clinical adoption.

Key Points

The study aimed to correlate pulmonary capillary wedge pressure estimated by Doppler echocardiography with invasive measurements from cardiac catheterization.
Patients underwent simultaneous cardiac catheterization and Doppler echocardiography.
Mitral flow velocity variables and maximal left atrial volume were analyzed using regression analyses.
An equation for noninvasive estimation of PCWP was derived from the Doppler data.
Significant negative correlation between deceleration time (r=-0.483; p=0.001) and ejection fraction (r=-0.334; p=0.01) with invasive PCWP.
Significant positive correlation of peak E wave (r=0.345; p=0.01) and deceleration rate (r=0.651; p=0.001) with catheter-derived PCWP.
The correlation coefficient between measured and estimated PCWP was r=0.678.

Study Design

Type

Cross-Sectional (n=50)

Blinding

Blinded observers

Multicenter

Structured PICO

Does Doppler echocardiography accurately estimate pulmonary capillary wedge pressure compared to invasive cardiac catheterization in patients with coronary artery disease?

Population

50 patients with coronary artery disease undergoing cardiac catheterization, evaluated to correlate noninvasive Doppler echocardiography estimates of pulmonary capillary wedge pressure with invasive measurements.

Exposure

Doppler echocardiography (mitral flow velocity variables and maximal left atrial volume)

Comparator

Invasive cardiac catheterization (catheter-derived PCWP)

Outcome

Correlation of Pulmonary Capillary Wedge Pressure (PCWP) estimated by Doppler echocardiography with that obtained at cardiac catheterizationsurrogate

Main Result

Effect estimate: r=0.678

p-value: p=0.001

Doppler echocardiography using transmitral flow velocity patterns and left atrial volume can noninvasively estimate pulmonary capillary wedge pressure with a clinically meaningful degree of accuracy in patients with coronary artery disease.

Limitations

Did not include patients with other diseases like cardiomyopathy, limiting generalizability.
Did not measure isovolumic relaxation time, a sensitive Doppler index.
PCWP was measured with a Cournand catheter instead of a Swan Ganz catheter.
Small sample size leading to non-significant results in some instances and lower correlation coefficients.

Cite This Study

Tamanna et al. (1970) conducted a cross-sectional in Coronary artery disease (n=50). Doppler echocardiography vs. Invasive cardiac catheterization was evaluated on Correlation between noninvasive estimated PCWP and invasive catheter-derived PCWP (r=0.678, p=0.001). Noninvasive estimation of pulmonary capillary wedge pressure using a Doppler echocardiography-derived equation incorporating mitral flow variables significantly correlated with invasive catheterization measurements (r=0.678).

synapsesocial.com/papers/6a5038e473bacd73dc7843d4 https://doi.org/10.3329/cardio.v1i2.8236

View Full Paper

Ask AI

Bookmark

Noninvasive Estimation of PCWP with Doppler Transmitral Flow Velocity Pattern in Patients with Coronary Artery Disease

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Main Result

Limitations

Cite This Study

Noninvasive Estimation of PCWP with Doppler Transmitral Flow Velocity Pattern in Patients with Coronary Artery Disease

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Main Result

Limitations

Cite This Study

Also Consider

Also Consider