Key result
Train stimulation induced triggered activity in 95.6% of isolated guinea-pig pulmonary vein preparations compared to 0% in the left atrium, which was suppressed by verapamil, ryanodine, pilsicainide, and carbachol.
Population
Isolated pulmonary vein preparations from guinea pigs (n=45)
Comparison
Train stimulation and exposure to… vs Isolated left atrium preparations
Design
Preclinical
Authors
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No change to clinical AF management warranted; leaves open translation of guinea pig pulmonary vein findings to human arrhythmias.
Absolute Event Rate: 95.6% vs 0%
Guinea pig pulmonary veins exhibit arrhythmogenic features with triggered activities that are absent in the left atrium, potentially due to a lower resting membrane potential, and are suppressible by specific pharmacological agents.
Takahara et al. (2011) studied Arrhythmogenesis (Triggered activity in pulmonary vein) (n=45). Train stimulation and pharmacological agents (verapamil, ryanodine, pilsicainide, carbachol) vs. Left atrium or pre-drug control was evaluated on Incidence of triggered activity after train stimulation at a pacing cycle length of 100 ms. Train stimulation induced triggered activity in 95.6% of isolated guinea-pig pulmonary vein preparations compared to 0% in the left atrium, which was suppressed by verapamil, ryanodine, pilsicainide, and carbachol.
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