Key result
Each 1-g/d increment in sodium excretion was not associated with CHD risk overall (HR 1.07; 95% CI 0.98-1.18; P=0.15), but increased risk in subjects with hypertension or elevated NT-proBNP.
Why the study?
Does higher sodium excretion increase the risk of developing coronary heart disease in adults free of cardiovascular and kidney disease?
Cohort (n=7,543)
Does higher sodium excretion increase the risk of developing coronary heart disease in adults free of cardiovascular and kidney disease?
Hazard Ratio: 1.07 (95% CI 0.98–1.18)
p-value: p=0.15
While overall sodium excretion was not associated with incident coronary heart disease in a general population, higher sodium intake may increase risk in susceptible individuals with hypertension or elevated NT-proBNP.
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May warrant sodium monitoring in hypertension or elevated NT-proBNP; hypothesis-generating for targeted restriction trials.
Joosten et al. (2014) conducted a cohort in Coronary heart disease (n=7,543). Sodium excretion was evaluated on Coronary heart disease events (HR 1.07, 95% CI 0.98-1.18, p=0.15). Each 1-g/d increment in sodium excretion was not associated with CHD risk overall (HR 1.07; 95% CI 0.98-1.18; P=0.15), but increased risk in subjects with hypertension or elevated NT-proBNP.
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