Key result
Urinary sodium excretion correlated with elevated blood pressure but demonstrated no pattern of increased cardiovascular disease, heart failure, or mortality risk across quintiles.
Why the study?
Observational studies have linked low sodium intake to increased mortality, requiring further assessment of whether confounding explains associations between sodium intake and outcomes.
Does urinary sodium excretion correlate with blood pressure and predict future cardiovascular disease, heart failure, or mortality in subjects without prior cardiovascular disease?
Cohort (n=457,484)
Does urinary sodium excretion correlate with blood pressure and predict future cardiovascular disease, heart failure, or mortality in subjects without prior cardiovascular disease?
While higher urinary sodium excretion correlates with elevated blood pressure, it does not predict an increased risk of cardiovascular disease, heart failure, or mortality in a low-risk cohort.
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Questions sodium restriction for CVD prevention despite BP link; leaves open causal role in primary prevention.
Welsh et al. (2019) conducted a cohort in Without prior cardiovascular disease (n=457,484). Urinary sodium excretion vs. Lower quintiles of sodium excretion was evaluated on Incidence of fatal and nonfatal cardiovascular disease, heart failure, and mortality. Urinary sodium excretion correlated with elevated blood pressure but demonstrated no pattern of increased cardiovascular disease, heart failure, or mortality risk across quintiles.
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