February 1, 1998European Heart Journal
Improvement in left ventricular ejection fraction and wall motion after successful recanalization of chronic coronary occlusions
Key result
Long-term patency after recanalization of chronic coronary occlusions significantly improved left ventricular ejection fraction compared to reocclusion (change of 0.05 vs 0.01; P=0.04).
Why the study?
Does successful recanalization of chronic coronary occlusions improve left ventricular ejection fraction and regional radial shortening in patients with angina pectoris or exercise-induced ischaemia?
Population
95 patients with angina pectoris or exercise-induced ischaemia with a successfully recanalized chronic…
Comparison
Successful angioplasty/recanalization of chronic… vs Baseline measurements and patients with…
Design
Cohort
Follow-up
6.7 +/- 1.4 months
Authors
Discussion
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Implication
May support LV recovery after CTO angioplasty; hypothesis-generating and should not change practice without RCTs.
Study Design
Type
Cohort (n=95)
Structured PICO
Does successful recanalization of chronic coronary occlusions improve left ventricular ejection fraction and regional radial shortening in patients with angina pectoris or exercise-induced ischaemia?
P
Population
95 patients with angina pectoris or exercise-induced ischaemia and a successfully recanalized chronic coronary occlusion, followed for a mean of 6.7 months.
E
Exposure
Successful angioplasty/recanalization of chronic coronary occlusions (intracoronary stents implanted in 71%)
C
Comparator
Baseline measurements and patients with reocclusion (n=8) at follow-up
O
Outcome
Changes in left ventricular ejection fraction and regional radial shortening at 6.7 +/- 1.4 monthssurrogate
Main Result
Absolute Event Rate: 0.05% vs 0.01%
p-value: p=0.04
Successful recanalization of chronic coronary occlusions is associated with significant improvements in global and regional left ventricular function at 6 months, provided the artery remains patent.
Cite This Study
Per Anton Sirnes (1998) conducted a cohort in Chronic coronary occlusions with angina pectoris or exercise-induced ischaemia (n=95). Patent artery after recanalization vs. Reocclusion was evaluated on Change in left ventricular ejection fraction (p=0.04). Long-term patency after recanalization of chronic coronary occlusions significantly improved left ventricular ejection fraction compared to reocclusion (change of 0.05 vs 0.01; P=0.04).