Assessment of acute changes in ventricular volumes, function, and strain after interventional edge-to-edge repair of mitral regurgitation using cardiac magnetic resonance imaging
Key result
MitraClip implantation significantly reduced MR fraction (36% vs 19%, P<0.001) and LV end-diastolic volume, but did not immediately improve cardiac index or biventricular forward flow.
Why the study?
Does MitraClip implantation improve acute ventricular volumes, function, and strain in patients with moderate to severe MR and high surgical risk?
Population
20 patients with moderate to severe mitral regurgitation and high surgical risk, mean age 76 ± 8 years, mean…
Comparison
MitraClip implantation vs Pre-procedure baseline
Design
Cohort
Follow-up
within 7 days after the procedure
Authors
Discussion
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Implication
Does not immediately improve forward flow despite MR reduction after MitraClip; leaves open whether remodeling yields later hemodynamic gains.
Study Design
Type
Observational (n=20)
Structured PICO
Does MitraClip implantation improve acute ventricular volumes, function, and strain in patients with moderate to severe MR and high surgical risk?
P
Population
20 high-surgical-risk patients (mean age 76) with moderate to severe mitral regurgitation undergoing MitraClip implantation, evaluated before and within 7 days post-procedure.
E
Exposure
MitraClip implantation (interventional edge-to-edge repair)
C
Comparator
Pre-procedure baseline
O
Outcome
Acute changes in ventricular volumes, function, and strain measured by cardiac magnetic resonance (CMR) imaging within 7 days after the proceduresurrogate
Main Result
Absolute Event Rate: 19% vs 36%
p-value: p=<0.001
MitraClip implantation in high-risk patients with moderate to severe MR acutely reduces MR and LV end-diastolic volume but does not immediately improve cardiac output or biventricular forward flow.
Cite This Study
Lurz et al. (2015) conducted an observational in Moderate to severe mitral regurgitation and high surgical risk (n=20). MitraClip implantation vs. Pre-procedure baseline was evaluated on Mitral regurgitation (MR) fraction (p=<0.001). MitraClip implantation significantly reduced MR fraction (36% vs 19%, P<0.001) and LV end-diastolic volume, but did not immediately improve cardiac index or biventricular forward flow.