Key result
Obesity linked to ~51% lower smoking odds versus underweight status in depression medication users.
Why the study?
Depression in individuals with obesity who smoke cigarettes is often complicated by potential smoking use for stress coping, leaving the mediating role of depression medication unclear across BMI categories.
Does depression medication mediate the association between Body Mass Index and cigarette smoking in US adults?
Population
Adults 18-65 years of age in the United States from the 2023 NHIS
Comparison
Depression medication use across obese, overweight, normal weight, and underweight categories
Design
Cross-sectional survey analysis using a Generalized Structural Equation Model
Authors
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Depression medication may mediate smoking across BMI groups; leaves open causal pathways pending longitudinal data.
Cross-Sectional
Yes
Does depression medication mediate the association between Body Mass Index and cigarette smoking in US adults?
Odds Ratio: 0.49 (95% CI 0.38–0.63)
Depression medication use mediates the relationship between BMI and smoking, suggesting BMI should be considered when planning smoking cessation interventions.
Onigbogi et al. (2026) conducted a cross-sectional in Smoking and obesity. Underweight BMI and depression medication vs. Obese BMI was evaluated on Smoking (aOR 0.49, 95% CI 0.38-0.63). Underweight participants on depression medication were more likely to smoke compared to obese participants (aOR 0.49; 95% CI 0.38-0.63).
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