Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
July 10, 2026Virology JournalOpen Access

Metabolic associated fatty liver disease induced hepatocyte apoptosis to eliminate hepatitis B virus

View Full Paper
Ask AI
Bookmark
Share

Authors

JYJiayu YuXZXin Zheng

Discussion

Loading...

Member takes

Overview

Randomized trial investigates HBV clearance in CHB patients with fatty liver, highlighting potential treatment strategies.

Key Points

  • This research aims to explore how metabolic dysfunction-associated fatty liver disease affects hepatitis B virus clearance through hepatocyte apoptosis.
  • Analyzed human liver transcriptome data comparing CHB patients with and without MAFLD.
  • Conducted in vitro experiments using palmitic acid to induce lipotoxicity and oleic acid to examine reversal effects in HepG2.2.15 cells.
  • Measured levels of HBsAg, HBeAg, and HBV-DNA via ELISA and PCR, while assessing mitochondrial membrane permeability and oxidative stress.
  • Palmitic acid significantly reduced HBsAg, HBeAg, and HBV-DNA levels in cell supernatants and lysates.
  • PA activated the apoptotic pathway by increasing mitochondrial membrane permeability and ROS levels, activating Caspase-9, PARP, and Caspase-3.
  • Oleic acid effectively reversed PA's effects by restoring mitochondrial function and decreasing apoptosis and oxidative stress.

Cite This Study

Yu et al. (2026) studied this question.

synapsesocial.com/papers/6a508c2d6eeac72a437a066ehttps://doi.org/10.1186/s12985-026-03218-x
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1[Altered oral microbiome and metabolites are associated with improved lipid metabolism in HBV-infected patients with metabolic dysfunction-associated fatty liver disease].2025 · 2 citations
  2. 2[Research progress on the impact of metabolic associated fatty liver disease on viral activity, treatment response, and prognosis in patients with chronic hepatitis B: current status and prospects].2025
  3. 3The coexistence of MAFLD increases fibrosis burden in patients with chronic hepatitis B2026
  4. 4Hepatitis B virus e antigen induces atypical metabolism and differentially regulates programmed cell deaths of macrophages2024 · 14 citations
  5. 5Steatosis Paradox: Unraveling Pathways of Suppressive Effect of Hepatic Steatosis on Hepatitis B Virus2026 · 1 citations