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July 10, 2026Romanian Journal of CardiologyOpen Access

Older age linked to ~800% higher CV mortality risk following a first STEMI.

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Why the study?

Myocardial infarction in young adults is increasingly recognized as a distinct clinical entity, but data from North African populations remain limited.

Population

206 patients who experienced a first STEMI

Comparison

Younger patients vs older patients stratified by age 50 years

Design

Retrospective comparative study

Follow-up

Minimum of 12 months

Key result

Older age (>50 years) was independently associated with a significantly higher risk of cardiovascular mortality compared to younger age (11% vs 0.9%, HR 8.98) in patients presenting with a first STEMI.

Authors

SHSofiene HaboubiMGMeriem GhozziaELElyes Lagha

Discussion

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Overview

Suggests age-specific risk modification in STEMI; leaves open whether tailored strategies improve outcomes.

Key Points

  • This study investigates the distinct risk profiles and cardiovascular outcomes of ST-segment elevation myocardial infarction in young and older patients.
  • Retrospective comparative study of patients with first ST-segment elevation myocardial infarction.
  • Patients were divided into two groups based on age, with a minimum follow-up of 12 months.
  • Data were collected from medical records.
  • Younger patients exhibited higher smoking rates (84.9% vs 60%, p < 0.05) and substantial alcohol use (30.2% vs 7%, p < 0.05).
  • Cardiovascular mortality was higher in older patients (11% vs 0.9%, p < 0.01).
  • The incidence of combined cardiovascular events was similar for both age groups (25.5% vs 26%, p = 0.96).

Study Design

Type

Observational (n=206)

Multicenter

No

Structured PICO

P
Population
206 patients with a first STEMI who underwent percutaneous coronary intervention, stratified by age (≤50 vs >50 years), followed for a mean of 38.7 months.
O
Outcome
cardiovascular mortalityhard clinical

Main Result

Hazard Ratio: 8.98 (95% CI 1.15–69.94)

Absolute Event Rate: 11% vs 0.9%

p-value: p=0.036

Young STEMI patients (<50 years) have distinct risk profiles and similar rates of non-fatal cardiovascular events compared to older patients, despite lower cardiovascular mortality.

Limitations

  • Monocentric design may limit the generalizability of the findings
  • Retrospective nature introduces potential selection and information biases
  • Relatively small sample size and limited number of events may have reduced statistical power
  • Absence of intracoronary imaging precludes a detailed mechanistic characterization of coronary lesions

Cite This Study

Haboubi et al. (2026) conducted an observational in ST-segment elevation myocardial infarction (STEMI) (n=206). Older age (>50 years) vs. Young age (≤50 years) was evaluated on Cardiovascular mortality (HR 8.98, 95% CI 1.15-69.94, p=0.036). Older age (>50 years) was independently associated with a significantly higher risk of cardiovascular mortality compared to younger age (11% vs 0.9%, HR 8.98) in patients presenting with a first STEMI.

synapsesocial.com/papers/6a508cc46eeac72a437a0ae7https://doi.org/10.2478/rjc-2026-0017
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