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July 10, 2026Journal of Paediatrics and Child Health

A Randomised Open‐Label Comparison of Dexamphetamine and Methylphenidate in Children With Attention Deficit Hyperactivity Disorder ( ADHD ): Symptom Response, Adherence and Weight Impact Over 12 Months

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Authors

APAlison PoultonThe University of SydneySNSharon NgNepean HospitalHDHoang Cuc DoNepean Hospital

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Implication

Randomized trial compares symptom response and adherence in children with ADHD, suggesting similar effectiveness.

Key Points

  • The aim is to compare the therapeutic effects and adverse outcomes of dexamphetamine and methylphenidate in children with ADHD.
  • Randomized, open-label design conducted in NSW, Australia.
  • Included 100 stimulant-naïve children/adolescents with DSM-5-confirmed ADHD.
  • Participants were followed for 12 months with weight-based dose titration.
  • Significant ADHD symptom improvement was observed with both medications (p = 0.001).
  • 62 participants remained on their allocated medication after 12 months, with no significant preference (p = 0.15).
  • Dexamphetamine was associated with greater weight loss at 3 months (-1.44 kg vs. -0.31 kg; p = 0.005).

Cite This Study

Poulton et al. (2026) studied this question.

synapsesocial.com/papers/6a508cc46eeac72a437a0af5https://doi.org/10.1111/jpc.70487
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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  2. 2Treatments for ADHD in Children and Adolescents: A Systematic Review2024 · 56 citations
  3. 3FACTORS INFLUENCING THE SUPPRESSANT EFFECTS OF TWO STIMULANT DRUGS ON THE GROWTH OF HYPERACTIVE CHILDREN1973 · 158 citations
  4. 4Side Effects of Metlyiphenidate in Children With Attention Deficit Hyperactivity Disorder: A Systemic, Placebo-Controlled Evaluation1990 · 374 citations
  5. 5Slowing of growth in height and weight on stimulants: A characteristic pattern2003 · 132 citations