October 1, 2002Journal of Clinical Psychopharmacology
Comparative Efficacy of Adderall and Methylphenidate in Attention-deficit/Hyperactivity Disorder: A Meta-Analysis
Key result
Adderall demonstrated a small but statistically significant advantage over standard-release methylphenidate for symptom measures and global ratings in children with ADHD.
Why the study?
Does Adderall improve symptoms compared to standard-release methylphenidate in children with ADHD?
Population
Children with attention-deficit/hyperactivity disorder (ADHD) from 4 studies
Comparison
Adderall vs Standard-release form of methylphenidate
Design
Meta-analysis
Authors
Discussion
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Implication
Small advantage supports individualized stimulant choice in pediatric ADHD; extends meta-analytic evidence on amphetamine formulations.
Study Design
Type
Meta-Analysis
Structured PICO
Does Adderall improve symptoms compared to standard-release methylphenidate in children with ADHD?
P
Population
Meta-analysis of 4 studies evaluating children with attention-deficit/hyperactivity disorder.
I
Intervention
Adderall
C
Comparator
Standard-release form of methylphenidate
O
Outcome
Efficacy based on symptom measures and global ratingspatient reported
Adderall provides a small but statistically significant efficacy advantage over standard-release methylphenidate in children with ADHD.
Cite This Study
Faraone et al. (2002) conducted a meta-analysis in Attention-deficit/Hyperactivity Disorder. Adderall vs. Methylphenidate (standard-release form) was evaluated on Symptom measures and global ratings. Adderall demonstrated a small but statistically significant advantage over standard-release methylphenidate for symptom measures and global ratings in children with ADHD.