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July 10, 2026Pediatric InvestigationOpen Access

Long‐term outcomes of haploidentical hematopoietic stem cell transplantation with antithymocyte globulin–based myeloablative conditioning in pediatric refractory or relapsed non‐Hodgkin lymphoma

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Authors

CJChenguang JiaJZJie ZhengMYMeng Yuan

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Overview

Randomized trial evaluates long-term efficacy of ATG-based haplo-HSCT in children with R/R NHL, suggesting its effectiveness.

Key Points

  • To assess the long-term efficacy and safety of ATG-based myeloablative haplo-HSCT in pediatric patients with refractory or relapsed non-Hodgkin lymphoma.
  • Pediatric patients with R/R NHL who had ATG-based haplo-HSCT were retrospectively enrolled from March 2015 to December 2021.
  • Overall survival (OS) and progression-free survival (PFS) were estimated using Kaplan–Meier methods and compared with the log-rank test.
  • A total of 29 patients were analyzed.
  • 5-year overall survival (OS) was 79.3%, and progression-free survival (PFS) was 72.4%.
  • Cumulative incidence of relapse was 10.0%, and non-relapse mortality was 17.0%.
  • Thrombotic microangiopathy (TMA) occurred in 12 patients, significantly impacting prognosis (P = 0.001).

Cite This Study

Jia et al. (2026) studied this question.

synapsesocial.com/papers/6a508d096eeac72a437a0cfehttps://doi.org/10.1002/ped4.70070
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