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July 26, 2026Discover OncologyOpen Access

Combination of post-transplant cyclophosphamide and anti-thymocyte globulin for haploidentical stem cell transplantation in pediatric patients with acute leukemia

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Authors

AKAzadeh KiumarsiTRTahereh RostamiMRMohammad Reza Rostami

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Overview

Randomized trial evaluates outcomes of dual T-cell depletion in pediatric patients with acute leukemia, suggesting feasible transplantation approach.

Key Points

  • This research aims to assess the outcomes of a combination transplant protocol in pediatric patients with acute leukemia.
  • Evaluated 70 pediatric patients undergoing haploidentical HSCT for acute leukemia.
  • Utilized a radiation-free myeloablative conditioning regimen including busulfan, cyclophosphamide, and rabbit ATG, followed by post-transplant cyclophosphamide.
  • Outcomes measured included engraftment, graft-versus-host disease, overall survival, and relapse incidences.
  • Successful engraftment in nearly 95% of patients within 30 days.
  • 2-year overall survival rate was 69.86%; GRFS was 35.76%.
  • T-cell acute lymphoblastic leukemia patients had significantly higher mortality and relapse rates.

Cite This Study

Kiumarsi et al. (2026) studied this question.

synapsesocial.com/papers/6a65a8c9d3aea3239cd7906dhttps://doi.org/10.1007/s12672-026-05001-4
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Dual T-cell depletion with individually tailored anti-thymocyte globulin and attenuated dose of post-transplant cyclophosphamide in haploidentical peripheral stem cell transplantation2024 · 8 citations
  2. 2Anti-thymocyte globulin combined with post-transplantation cyclophosphamide reduce graft-versus-host disease in hematopoietic stem cell transplantation for pediatric leukemia2024 · 3 citations
  3. 3Long-term outcome of children with acute lymphoblastic leukemia after hematopoietic stem cell transplantation based on ex-vivo alpha-beta T cell depletion2026
  4. 4Expanding access in pediatrics: Outcomes of haploidentical transplantation with reduced intensity and peripheral blood stem cells2025
  5. 5Long‐term outcomes of haploidentical hematopoietic stem cell transplantation with antithymocyte globulin–based myeloablative conditioning in pediatric refractory or relapsed non‐Hodgkin lymphoma2026