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July 10, 2026Advanced Materials

Biomimetic Surface Nanoengineering of Biodegradable Zn‐Based Membranes Enables Phase‐Specific Metal Ion Delivery for Synergistic Anti‐Infection and Bone Regeneration

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Authors

KCKeping ChenChinese Academy of Medical Sciences & Peking Union Medical CollegeATAnqi TaoShanghai University of Engineering ScienceJDJiale DongShandong University

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Overview

Randomized trial demonstrates antibacterial effectiveness and enhanced bone regeneration in GBR membranes, implying potential for dental treatments.

Key Points

  • The aim is to develop a Zn-based membrane that balances antibacterial activity and osteogenic potential for guided bone regeneration.
  • Engineered a polydopamine-based nanohybrid coating on Zn membranes with controlled Cu2+ concentrations.
  • Analyzed ion release kinetics in relation to bone healing phases including infection control and mineralization.
  • Evaluated mechanical stability and bacteriostatic properties of the membranes against various bacteria.
  • Significantly improved antibacterial effectiveness against microbial strains with synergistic Zn2+/Cu2+ release.
  • Enhanced mechanical stability with resistance to deformation-induced microcracks was observed.
  • Phase-specific ion release kinetics adjusted dynamically to align with different stages of bone healing.

Cite This Study

Chen et al. (2026) studied this question.

synapsesocial.com/papers/6a508d536eeac72a437a0d74https://doi.org/10.1002/adma.202523183
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