What question did this study set out to answer?

Investigate a new bilayer nanofibrous membrane to enhance guided bone regeneration and improve mechanical and antibacterial properties.

An Engineered Multifunctional Asymmetric Bilayer Nanofibrous Membrane of GO@PLGA/PVA-Mg for Guided Bone Tissue Regeneration

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Novel bilayer membranes promote bone healing in alveolar defects, indicating a potential clinical advancement.

Investigate a new bilayer nanofibrous membrane to enhance guided bone regeneration and improve mechanical and antibacterial properties.
Fabricated an asymmetric bilayer membrane using coaxial electrospinning.
Outer layer composed of dense PLGA-GO/PVA-MgCl2; inner layer made of porous PLGA-GO/PVA-MgCl2.
Evaluated mechanical properties, degradation rate, antibacterial activity, and cell behavior in vitro and in vivo.
Young’s modulus of 84.8 MPa indicating good mechanical strength.
23% degradation over 2 months showing matched stability to commercial membranes.
Significantly enhanced osteoblast migration and differentiation in the presence of the porous layer.
Excellent antibacterial activity and cytocompatibility demonstrated in vitro, leading to improved bone healing in rat models.

Zhang et al. (2026) studied this question.

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