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July 10, 2026NutrientsOpen Access

Therapeutic Effects of Dihydromyricetin on Wholly Alcohol-Attributed Conditions: A Systematic Review

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Authors

SSSamantha G. SkinnerSMSaikumar MatchaDDDaryl L. Davies

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Overview

Systematic review evaluates Dihydromyricetin's effects on alcohol-related conditions, indicating potential benefits.

Key Points

  • This review assesses the therapeutic effects of Dihydromyricetin on conditions linked to alcohol consumption, including liver disease and alcohol use disorder.
  • Systematic literature search in PubMed from inception through December 2025 on studies regarding DHM effects on alcohol-related outcomes.
  • Included 22 studies: 8 in vitro, 17 in vivo, and 2 clinical trials, assessing study quality qualitatively without a risk-of-bias tool.
  • Findings synthesized narratively without meta-analysis due to study heterogeneity.
  • DHM consistently reduced ethanol-induced cytotoxicity, oxidative stress, and inflammation across various models.
  • Improved liver injury biomarkers (e.g., AST and ALT) and enhanced antioxidant defenses linked to DHM treatment.
  • Limited clinical trials showed reduction in hangover severity but lacked direct evaluation of isolated DHM.

Cite This Study

Skinner et al. (2026) studied this question.

synapsesocial.com/papers/6a508d536eeac72a437a0dcehttps://doi.org/10.3390/nu18142221
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Modulatory Effect of Dihydromyricetin on Chronic Alcoholic Liver Injury Based on the FXR-NLRP3 Signaling Pathway and Serum and Liver Metabolomics2024
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  3. 3Hovenia dulcis Fruit Peduncle Polysaccharides Reduce Intestinal Dysbiosis and Hepatic Fatty Acid Metabolism Disorders in Alcohol-Exposed Mice2024 · 12 citations
  4. 4Dietary Dihydromyricetin Supplementation Enhances Antioxidant Capacity and Modulates Jejunal Barrier Function, Cecal Microbiota, and Hepatic Metabolism in Mice2026
  5. 5Dihydromyricetin mitigates T2DM progression by modulating bile acid metabolism through SHP/PPARγ pathway2026