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July 10, 2026DiagnosticsOpen Access

Current Landscape of Molecular Diagnostic Tests and Emerging Tools for Tuberculosis and Drug Resistance

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Authors

SKSafaa El KassimiMohammed V UniversityRERkia EddabraÉcole PolytechniqueBBBouchra BelkadiMohammed V University

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Implication

Review highlights advances in molecular diagnostics for tuberculosis, addressing drug resistance and optimizing care.

Key Points

  • This review aims to summarize recent advances in molecular diagnostic tests for tuberculosis and their role in drug resistance detection.
  • Examined WHO-endorsed nucleic acid amplification tests (NAATs) for TB and drug resistance.
  • Analyzed diagnostic performance across various assay technologies, including cartridge-based, line probe assays, and sequencing.
  • Explored emerging tools and diagnostic innovations for decentralized testing and improved patient outcomes.
  • Low- and moderate-complexity assays like Xpert® MTB/RIF are essential for TB diagnosis in decentralized settings.
  • Advanced tools like Xpert® XDR and TBseq® enable comprehensive resistance detection for multidrug-resistant TB.
  • Identified performance gaps, including limited sensitivity in certain diseases and infrastructure challenges that hinder universal adoption.

Cite This Study

Kassimi et al. (2026) studied this question.

synapsesocial.com/papers/6a508df96eeac72a437a12cdhttps://doi.org/10.3390/diagnostics16132133
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Current Landscape of Molecular Diagnostic Tests for Tuberculosis and Drug Resistance: From Routine Practice to Emerging Technologies2025
  2. 2Diagnostic Assays for TB Disease and Drug Resistance Detection—Advances and Latest WHO Recommendations2026
  3. 3Next-Generation Tuberculosis Diagnostics: A Detailed Review of Emerging Tools and Global Trends2026
  4. 4Evolution of Mycobacterium Tuberculosis Diagnostics: From Classic Methods to High-Resolution Molecular Platforms:A Literature Review2025
  5. 5Exploring Diagnostic Methods for Drug-Resistant Tuberculosis: A Comprehensive Overview2024 · 1 citations