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July 10, 2026CureusOpen Access

Mycoplasma pneumoniae-Associated Reactive Infectious Mucocutaneous Eruption Mimicking Atypical Stevens-Johnson Syndrome: A Case Report

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Authors

ABAlexandru C BurbeaPVPankaj VerlekarRoyal Hampshire County Hospital

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Overview

Case report shows ocular and oral mucositis mimicking Stevens-Johnson syndrome, indicating diagnostic challenges.

Key Points

  • This report aims to highlight the diagnostic complexities of Mycoplasma pneumoniae-associated reactive infectious mucocutaneous eruption mimicking atypical Stevens-Johnson syndrome.
  • Case presentation of a previously healthy woman in her 20s with respiratory symptoms leading to mucosal involvement.
  • Utilization of serology testing for Mycoplasma pneumoniae IgM and drug challenge testing to affirm diagnosis.
  • Multi-disciplinary assessment including ophthalmology for severe ocular involvement.
  • Patient exhibited progressive lip swelling, oral ulceration, and severe bilateral ocular inflammation after respiratory symptoms.
  • Serology confirmed Mycoplasma pneumoniae infection after initial negative PCR results.
  • Prompt involvement from dermatology and ophthalmology was crucial in managing severe ocular morbidity.

Cite This Study

Burbea et al. (2026) studied this question.

synapsesocial.com/papers/6a508e5b6eeac72a437a149chttps://doi.org/10.7759/cureus.112262
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Stevens–Johnson syndrome without skin lesions2007 · 41 citations
  2. 2Atypical Stevens-Johnson Syndrome Associated With Mycoplasma Pneumoniae2022 · 5 citations
  3. 3Diagnosis and management of reactive infectious mucocutaneous eruption2025 · 12 citations
  4. 4Amniotic membrane grafting for acute ocular involvement in Stevens-Johnson syndrome: Review of perioperative considerations, surgical techniques, and outcomes2025 · 6 citations