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This study evaluates the association between inflammatory markers and cholesteatoma staging to understand disease severity better.

July 11, 2026CureusOpen Access

The Systemic Immune Signature of Cholesteatoma: A Comprehensive Cross-Sectional Analysis of Hematological Markers and Clinical Staging

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Prospective analysis evaluates inflammatory markers' relationship with cholesteatoma staging, indicating potential assessment utility.

This study evaluates the association between inflammatory markers and cholesteatoma staging to understand disease severity better.
Prospective cross-sectional study conducted over 18 months at a tertiary care center with 72 patients.
Blood examinations included complete blood count, erythrocyte sedimentation rate, and C-reactive protein.
Kruskal-Wallis test and Spearman’s rank correlation were used to assess associations between markers and disease stages.
Stage II cholesteatoma was the most common, seen in 55.6% of cases.
The Systemic Immune-Inflammation Index increased significantly with disease stage, from 286.5 in stage I to 1304.0 in stage IV.
Significant positive correlations between certain inflammatory markers and disease stage were found.

Chauhan et al. (2026) studied this question.

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July 11, 2026CureusOpen Access

View Full Paper

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Authors

Prospective analysis evaluates inflammatory markers' relationship with cholesteatoma staging, indicating potential assessment utility.

This study evaluates the association between inflammatory markers and cholesteatoma staging to understand disease severity better.
Prospective cross-sectional study conducted over 18 months at a tertiary care center with 72 patients.
Blood examinations included complete blood count, erythrocyte sedimentation rate, and C-reactive protein.
Kruskal-Wallis test and Spearman’s rank correlation were used to assess associations between markers and disease stages.
Stage II cholesteatoma was the most common, seen in 55.6% of cases.
The Systemic Immune-Inflammation Index increased significantly with disease stage, from 286.5 in stage I to 1304.0 in stage IV.
Significant positive correlations between certain inflammatory markers and disease stage were found.

Chauhan et al. (2026) studied this question.

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