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July 11, 2026Scientific ReportsOpen Access

Optimization and bioactivity assessment of Sparassis crispa extracts with response surface methodology and artificial neural network-genetic algorithm

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Authors

CBCelal Bal

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Overview

Randomized trial evaluates the antioxidant and antiproliferative effects of optimized Sparassis crispa extracts, suggesting potential health benefits.

Key Points

  • The aim is to optimize and assess the biological activities of Sparassis crispa extracts using advanced techniques.
  • Extracts of Sparassis crispa were collected from Istanbul and optimized using Response Surface Methodology (RSM) and ANN-GA.
  • Bioactivity assessments included antioxidant and anticholinesterase activities and antiproliferative effects against cancer cell lines.
  • Phenolic compound profiles were analyzed using liquid chromatography-tandem mass spectrometry (LC-MS/MS).
  • The ANN-GA optimized extract demonstrated higher antioxidant capacity with TAS of 3.614 mmol/L, DPPH of 95.89 mg Trolox equivalents/g, and FRAP of 142.45 mg Trolox equivalents/g.
  • The ANN-GA extract showed lower Total Oxidant Status (TOS) and Oxidative Stress Index (OSI) values compared to the RSM extract.
  • Higher levels of phenolic compounds (gallic acid, caffeic acid, and protocatechuic acid) were found in the ANN-GA optimized extract.

Cite This Study

Celal Bal (2026) studied this question.

synapsesocial.com/papers/6a51dce1c18d7f28ca4ffdb4https://doi.org/10.1038/s41598-026-61731-z
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