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This study aims to characterize iron metabolism in dogs with cardiac disease, focusing on potential alterations indicative of an iron-restricted phenotype.

July 11, 2026BiomoleculesOpen Access

Altered Iron Metabolism in Dogs with Naturally Occurring Cardiac Disease

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CFCarolina Frizzo-RamosUniversity of Veterinary Medicine Vienna PDPavlos G. DoulidisUniversity of Veterinary Medicine Vienna UKUrsula S. KolmUniversity of Veterinary Medicine Vienna

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Randomized trial investigates iron metabolism alterations in dogs with cardiac disease, suggesting inflammation impacts iron handling.

Key Points

This study aims to characterize iron metabolism in dogs with cardiac disease, focusing on potential alterations indicative of an iron-restricted phenotype.
Evaluated hematologic indices, serum iron, TIBC, UIBC, ferritin, hepcidin, ceruloplasmin, C-reactive protein, and albumin in 61 dogs.
Divided the population into healthy controls, compensated cardiac disease (CCD) group, and acute decompensated congestive heart failure (ADCHF) group.
Analyzed the relationship between iron parameters and indices of cardiac remodeling.
Dogs with cardiac disease showed reduced hematocrit, increased red blood cell distribution width, and decreased circulating iron.
Both cardiac groups had lower TIBC and UIBC, indicating decreased transferrin availability and iron transport capacity.
Hepcidin concentrations were lower in CCD but not elevated in ADCHF, reflecting complex regulation of iron homeostasis.

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Frizzo-Ramos et al. (2026) studied this question.

synapsesocial.com/papers/6a51ddbfc18d7f28ca5001aa https://doi.org/10.3390/biom16070997

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Altered Iron Metabolism in Dogs with Naturally Occurring Cardiac Disease

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Cite This Study

Altered Iron Metabolism in Dogs with Naturally Occurring Cardiac Disease

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Implication

Key Points

Cite This Study

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