Key result
There were no statistically significant differences in iron concentration, ferritin concentration, total iron-binding capacity, or transferrin saturation between healthy cats and cats with hypertrophic cardiomyopathy with or without congestive heart failure.
Why the study?
Iron deficiency is an established comorbidity in human and canine heart failure, but no research had evaluated the role of iron in feline hypertrophic cardiomyopathy.
Does iron status differ in cats with hypertrophic cardiomyopathy with and without congestive heart failure compared to healthy controls?
Cross-Sectional (n=45)
No
Does iron status differ in cats with hypertrophic cardiomyopathy with and without congestive heart failure compared to healthy controls?
p-value: p=0.3
Unlike in humans and dogs, iron status markers do not significantly differ between healthy cats and those with hypertrophic cardiomyopathy with or without congestive heart failure.
Background: All organisms need iron for their survival and metabolic activity, and the healing process of patients depends on this element. Hence, its deficiency can negatively affect patients’ quality of life and cause disorders. Although iron deficiency is proven an important comorbidity in human and canine patients with heart failure, no research has been published on the role of iron in feline hypertrophic cardiomyopathy. Objectives: This research aimed to determine and compare the iron status of cats with hypertrophic cardiomyopathy with and without congestive heart failure. Methods: Based on laboratory, radiographic, and echocardiographic findings, 45 client-owned cats were studied and divided into three groups: control, hypertrophic cardiomyopathy (HCM) without congestive heart failure, and hypertrophic cardiomyopathy with congestive heart failure. Iron and ferritin concentrations, total iron-binding capacity (TIBC), and serum transferrin saturation (TSAT) percentage were measured and compared in all cats. Statistical nonparametric testing was used to analyze the data. Results: No groups illustrate any statistically significant difference for iron concentration (P=0.3), ferritin concentration (P=0.853), TIBC (P=0.1), and TSAT (P=0.639). The highest iron concentration and the lowest transferrin level and the transferrin saturation percentage were observed in the HCM group with congestive heart failure. Also, cats without congestive heart failure had the lowest TIBC compared to other groups. Conclusion: Unlike previous studies in dogs and humans, our study did not show a significant difference between cats with hypertrophic cardiomyopathy regarding iron status.
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Seyednejad et al. (2023) conducted a cross-sectional in Hypertrophic Cardiomyopathy (HCM) with and without congestive heart failure in cats (n=45). Hypertrophic cardiomyopathy with or without congestive heart failure vs. Healthy control cats was evaluated on Iron concentration (p=0.3). There were no statistically significant differences in iron concentration, ferritin concentration, total iron-binding capacity, or transferrin saturation between healthy cats and cats with hypertrophic cardiomyopathy with or without congestive heart failure.
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