What question did this study set out to answer?

This research aims to investigate the factors contributing to physical and mental health multimorbidity in South Asian populations in the UK.

July 11, 2026PLoS MedicineOpen Access

Genetic and sociodemographic factors associated with trajectories of physical and mental health multimorbidity in a South Asian cohort in the UK: A multistate modelling analysis

View Full Paper

Ask AI

Bookmark

Authors

DSDaniel StowQueen Mary University of London RTRuby S. M. TsangUniversity of Bristol IKIoanna KatzourouLiving Independently Now Center

Discussion

Member takes

Implication

Randomized trial evaluates the impact of genetic and sociodemographic factors on health outcomes in South Asian populations, suggesting early intervention strategies for high-risk groups.

Key Points

This research aims to investigate the factors contributing to physical and mental health multimorbidity in South Asian populations in the UK.
Longitudinal analysis of 23,554 British Bangladeshi and Pakistani participants
Use of multi-state models to assess health state transitions and associated risks
Adjustment for sociodemographic factors and polygenic risk score in health event predictions.
13.4% developed internalising and cardiometabolic multimorbidity; 6.5% had cardiovascular events; 0.4% experienced non-CVR deaths.
Higher incidence of multimorbidity in women, younger participants, and those with Bangladeshi ethnicity, high deprivation, or smoking history.
10-year cardiovascular risk was greater for those transitioning from cardiometabolic to internalising conditions versus the reverse.

Cite This Study

Stow et al. (2026) studied this question.

synapsesocial.com/papers/6a51de38c18d7f28ca5002dc https://doi.org/10.1371/journal.pmed.1004844

View Full Paper

Ask AI

Bookmark

Implication

Randomized trial evaluates the impact of genetic and sociodemographic factors on health outcomes in South Asian populations, suggesting early intervention strategies for high-risk groups.

Genetic and sociodemographic factors associated with trajectories of physical and mental health multimorbidity in a South Asian cohort in the UK: A multistate modelling analysis

Discussion

Member takes

Implication

Key Points

Cite This Study

Genetic and sociodemographic factors associated with trajectories of physical and mental health multimorbidity in a South Asian cohort in the UK: A multistate modelling analysis

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider