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July 11, 2026Annals of General PsychiatryOpen Access

C-reactive protein-triglyceride-glucose index and risk of incident depressive symptoms in older adults: an eight-year follow-up study from ELSA

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Key result

Higher CRP-TyG index linked to ~25% greater risk of depressive symptoms per SD.

  • HR 1.253
  • 95% CI 1.002-1.479
  • P=0.035
  • n=2,813

Why the study?

Prospective evidence on whether the C-reactive protein-triglyceride-glucose index, reflecting inflammatory-metabolic dysregulation, predicts incident depressive symptoms in aging populations is limited.

Does a higher baseline CRP-TyG index predict an increased risk of incident depressive symptoms in older adults?

Population

2,813 depression-free participants aged ≥ 50 years in ELSA

Comparison

Higher vs lower baseline CTI (per 1-SD increase)

Design

Nationally representative prospective cohort study

Follow-up

Eight-year follow-up (through Wave 8)

Authors

MGMixue GuoFujian University of Traditional Chinese MedicineMCMengyuan CaiErasmus MCHDHuqiang DongNingxia Medical University

Discussion

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Implication

May support CTI as a depressive risk marker in older adults; hypothesis-generating and requires validation before clinical adoption.

Key Points

  • This research aims to evaluate the association between the C-reactive protein-triglyceride-glucose index and the onset of depressive symptoms in older adults.
  • Analyzed data from 2,813 participants aged ≥ 50 in ELSA with follow-up through Wave 8.
  • CTI was assessed from fasting blood biomarkers, and depressive symptoms were evaluated using the CES-D-8 scale.
  • Cox proportional hazards models estimated hazard ratios, with multiple-imputation sensitivity analysis for missing data.
  • During follow-up, 136 participants developed incident depressive symptoms.
  • Each 1-SD increase in CTI was associated with an increased risk of depressive symptoms (HR = 1.253; 95% CI: 1.002–1.479; p = 0.035).
  • Multiple-imputation analyses showed directionally consistent results, supporting the primary findings.

Study Design

Type

Cohort (n=2,813)

Structured PICO

Does a higher baseline CRP-TyG index predict an increased risk of incident depressive symptoms in older adults?

P
Population
2,813 depression-free adults aged ≥ 50 years in England, followed for eight years to assess the risk of incident depressive symptoms.
E
Exposure
Higher baseline C-reactive protein-triglyceride-glucose index (CTI) assessed from fasting blood biomarkers
C
Comparator
Lower baseline CTI (analyzed per 1-SD increase)
O
Outcome
Incident depressive symptoms evaluated using the CES-D-8 scalepatient reported

Main Result

Hazard Ratio: 1.253 (95% CI 1.002–1.479)

p-value: p=0.035

Higher baseline CRP-TyG index is prospectively associated with an increased risk of incident depressive symptoms in older adults, suggesting its potential as a scalable risk biomarker.

Cite This Study

Guo et al. (2026) conducted a cohort in incident depressive symptoms (n=2,813). CRP-TyG index (CTI) was evaluated on incident depressive symptoms (HR 1.253, 95% CI 1.002-1.479, p=0.035). Each 1-SD increase in baseline CRP-TyG index was associated with a higher risk of incident depressive symptoms in older adults (HR 1.253; 95% CI 1.002-1.479; p=0.035).

synapsesocial.com/papers/6a51df22c18d7f28ca5007f2https://doi.org/10.1186/s12991-026-00690-1
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Association between C-reactive protein-triglyceride glucose index and depressive symptoms in American adults: results from the NHANES 2005 to 20102024 · 66 citations
  2. 2Joint Associations of Cumulative C-Reactive Protein–Triglyceride–Glucose Index and Depression with Cardiovascular Outcomes in Middle-Aged and Older Adults: A National Prospective Cohort Study2026
  3. 3Association of C-reactive protein-triglyceride glucose index with the incidence and mortality of cardiovascular disease: a retrospective cohort study2025 · 94 citations
  4. 42229-P: Association between C-Reactive Protein–Triglyceride–Glucose Index and New-Onset Chronic Disease Incidence and Mortality: Evidence from Multinational Cohorts2026
  5. 5Association between the C-reactive protein–triglyceride–glucose index and risks of all-cause and cardiovascular mortality in USA adults: a prospective cohort study2026