Key result
Elevated C-reactive protein-triglyceride glucose index linked to ~30% higher odds of depressive symptoms per SD.
Why the study?
Inflammation and insulin resistance are potential mechanisms underlying depressive symptoms, prompting investigation into their integrated measure, the serum C-reactive protein-triglyceride glucose index.
Is the C-reactive protein-triglyceride glucose index (CTI) associated with depressive symptoms in American adults?
Population
5,954 American adults from NHANES 2005 to 2010
Comparison
CTI levels across continuous scale and quartiles
Design
Cross-sectional study
Authors
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CTI-depression association in cross-sectional data needs prospective validation; leaves open its role in risk stratification.
Cross-Sectional (n=5,954)
Is the C-reactive protein-triglyceride glucose index (CTI) associated with depressive symptoms in American adults?
Odds Ratio: 1.3 (95% CI 1.06–1.61)
p-value: p=0.02
Elevated C-reactive protein-triglyceride glucose index (CTI) is significantly associated with a higher risk of depressive symptoms in American adults, suggesting its potential utility as a clinical indicator.
Huang et al. (2024) conducted a cross-sectional in Depressive symptoms (n=5,954). C-reactive protein-triglyceride glucose index (CTI) vs. Lower CTI levels was evaluated on Depressive symptoms (PHQ-9 score ≥ 10) (OR 1.30, 95% CI 1.06-1.61, p=0.02). Elevated C-reactive protein-triglyceride glucose index was significantly associated with a higher risk of depressive symptoms, with each standard deviation increase raising the odds by 30% (OR 1.30).
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