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July 11, 2026MoleculesOpen Access

Plant- and Algae-Derived Compounds Enhance the Anticancer Activity of Doxorubicin in Colorectal Cancer Cell Lines

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Authors

JRJosé Alberto Ramos-SilvaUniversidad Autónoma de Nuevo LeónGLGabriel Lara-HernándezSecretaría de Salud de JaliscoJFJosé Antonio Fuentes-GaribayUniversidad Autónoma de Nuevo León

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Overview

Randomized trial evaluates anticancer effects of plant and algae compounds in colorectal cancer, suggesting improved therapies.

Key Points

  • This study aims to investigate how plant- and algae-derived compounds can enhance the anticancer effects of doxorubicin in colorectal cancer.
  • Evaluated formulations enriched in fucoxanthin, fucoidan, tocotrienols, astaxanthin, and apple polyphenols.
  • Conducted cytotoxicity screening in ovarian, prostate, and colorectal cancer cells, including Caco2 and HT-29.
  • Assessed apoptosis-related effects through caspase-3/7 activation and spheroid model growth.
  • Caco2 cell viability decreased to approximately 10% with combined DOX and formulations compared to individual treatments.
  • Combined treatments significantly enhanced caspase-3/7 activation, indicating increased apoptosis.
  • Spheroid growth of HT-29 cells was reduced by approximately 30-35%, achieving effects similar to DOX alone.

Cite This Study

Ramos-Silva et al. (2026) studied this question.

synapsesocial.com/papers/6a51df9fc18d7f28ca5008adhttps://doi.org/10.3390/molecules31142414
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effect of Natural Products in the Prevention and Treatment of Colorectal Cancer2026
  2. 2The Red Algae<i>Jania rubens</i>Sensitizes Colon Cancer Cells to Doxorubicin Chemotherapy2024 · 2 citations
  3. 3Combined treatment with Aronia berry extract and oligomeric proanthocyanidins exhibit a synergistic anticancer efficacy through LMNB1‐AKT signaling pathways in colorectal cancer2024 · 1 citations
  4. 4Anti-proliferation effects of oxaliplatin in combination with the probiotic Lactobacillus acidophilus in colorectal cancer cells2026
  5. 5Mechanistic insights of clinically investigated natural products as anti-colorectal cancer agents2026