Key result
Fibrous cap degradation triggers plaque rupture, precipitating ~75% of fatal coronary thrombi.
Review highlights how plaque rupture leads to atherothrombosis, focusing on rupture-prone plaques.
Plaque rupture precipitates approximately 75% of all fatal coronary thrombi. Therefore, the plaque prone to rupture is the primary focus of this review. The lipid-rich core and fibrous cap are pivotal in the understanding of plaque rupture. Plaque rupture is a localized process within the plaque caused by degradation of a tiny fibrous cap rather than by diffuse inflammation of the plaque. Atherosclerosis is a multifocal disease, but plaques prone to rupture seem to be oligofocal at most.
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Thim et al. (2008) conducted a review in Atherothrombosis and vulnerable plaque. Plaque rupture is a localized process driven by degradation of a fibrous cap, precipitating approximately 75% of all fatal coronary thrombi.
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