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This research aims to understand the molecular basis of clonal diversity in grapevine through a comprehensive genome and methylome analysis.

July 12, 2026Genome biologyOpen Access

A dual genome-methylome map of clonal evolution in grapevine

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Randomized trial uncovers clonal genetic and DNA methylation differences in grapevine, suggesting implications for crop diversity.

This research aims to understand the molecular basis of clonal diversity in grapevine through a comprehensive genome and methylome analysis.
Generated a phased diploid reference genome for Pinot noir using Oxford Nanopore sequencing.
Analyzed DNA methylation and somatic genetic variation across 23 distinct clones of Vitis vinifera.
Documented 67,277 SNPs, 4,037 structural variants, and 15,986 CG, 52,158 CHG, and 32,062 CHH methylation polymorphisms.
Identified that approximately 12% of the grapevine genome contains extended runs of homozygosity due to ancient inbreeding.
Observed that somatic variation is predominated by rare variants with structural variation linked to repetitive DNA.
Detected strong enrichment of DNA methylation variation within gene bodies, highlighting its role in clonal divergence.

Callipo et al. (2026) studied this question.

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