What does this research mean for the field?

Compressed-sensing accelerated cine cardiac magnetic resonance provides equivalent evaluation of left ventricular ejection fraction and functional parameters compared to standard segmented cine imaging with comparable overall image quality. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To assess the consistency of left ventricular functional characteristics and image quality between compressed-sensing accelerated cine and standard segmented cine cardiac magnetic resonance sequences.

July 12, 2026BMC Medical ImagingOpen Access

Performance of compressed-sensing cardiac accelerated cine MR in evaluating left ventricular function: a systematic review and meta-analysis

Q: What are the key findings of this study?

Compressed-sensing accelerated cine imaging did not differ from standard segmented cine imaging in evaluating left ventricular ejection fraction (SMD -0.05).

Q: What is the clinical evidence from this study?

Study design: Meta-Analysis. Population: Left ventricular function evaluation (n=1969). Intervention: Compressed-sensing (CS) accelerated cine CMR vs. Standard segmented cine (Std-cine) CMR. Primary outcome: Left ventricular ejection fraction (LVEF) (SMD -0.05, 95% CI -0.11, 0.01, p=0.12).

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Key result

Compressed-sensing cine CMR yields similar LVEF measurements to standard segmented cine imaging.

SMD -0.05
95% CI -0.11, 0.01
P=0.12
n=1,969

Why the study?

To assess the consistency of left ventricular characteristics on cine CMR acquired from compressed-sensing accelerated cine versus standard segmented cine sequences.

Does compressed-sensing accelerated cine CMR provide consistent left ventricular characteristics compared to standard segmented cine CMR in patients undergoing cardiac MRI?

Comparison

Compressed-sensing accelerated cine vs standard segmented cine sequences

Design

Systematic review and meta-analysis

Authors

ZWZhaozhao WangWuhan Technology and Business University HKHuihui KongChina-Japan Friendship Hospital ZZZekun ZhouUniversity of Electronic Science and Technology of China

Discussion

Member takes

Implication

Supports compressed-sensing cine as equivalent for LVEF assessment; reinforces consistency with standard sequences across studies.

Key Points

To assess the consistency of left ventricular functional characteristics and image quality between compressed-sensing accelerated cine and standard segmented cine cardiac magnetic resonance sequences.
Conducted a systematic review and meta-analysis (PROSPERO CRD42022328219) of 35 observational studies encompassing 1,969 participants who underwent both compressed-sensing cine (CS-cine) and standard segmented cine (Std-cine) balanced steady-state free precession imaging.
Extracted separate measurements for left ventricular ejection fraction (LVEF), volumes, myocardial mass, and image quality across included adult and pediatric cohorts.
Performed subgroup analyses stratified by patient age, breath-holding capability versus free-breathing, presence of arrhythmia, and MRI magnetic field strength (1.5 T vs 3.0 T).
Left ventricular ejection fraction did not differ between CS-cine and Std-cine (standardized mean difference [SMD]: −0.05; 95%CI: −0.11, 0.01; p = 0.12; I2 = 0.0%), nor did end-diastolic volume, end-systolic volume, or LV mass (all I2 = 0.0%).
Overall image quality was comparable between CS-cine and Std-cine sequences (SMD: −0.36; 95%CI: −0.65, 0.08; p < 0.05; I2 = 37%), with no significant difference in quality among participants with arrhythmias (SMD: −0.04; 95%CI: −1.26, 1.18; p = 0.95; I2 = 87%).
CS-cine reduced total acquisition time by approximately 80% (from 254±153 seconds to 52±57 seconds) and reduced required breath-holds by approximately 50% (from 9.7±4.1 to 5.3±3.5).

Study Design

Type

Meta-Analysis (n=1,969)

Structured PICO

Does compressed-sensing accelerated cine CMR provide consistent left ventricular characteristics compared to standard segmented cine CMR in patients undergoing cardiac MRI?

Population

1,969 participants across 35 observational studies undergoing both compressed-sensing accelerated and standard segmented cine cardiac magnetic resonance imaging for left ventricular function evaluation.

Intervention

Compressed-sensing (CS) accelerated cine CMR sequence

Comparator

Standard segmented cine (Std-cine) CMR sequence (conventional multi-breath-hold segmented cine imaging)

Outcome

Left ventricular ejection fraction (LVEF)surrogate

Main Result

Standardized Mean Difference: -0.05 (95% CI -0.11–0.01)

p-value: p=0.12

Compressed-sensing accelerated cine CMR provides accurate left ventricular functional parameters comparable to standard cine imaging while significantly reducing scan time and breath-holds, and offering superior image quality in patients with arrhythmias.

Limitations

Different CS-cine sequence parameters, cardiac scanning plans, MRI machines, and image analysis software were used in the included studies.
Did not investigate LV global longitudinal strain.
Performance of CS-cine imaging in evaluating right ventricular function is unknown.
Did not refer to an optimal scanning order of the CS-cine sequence.
Generalizing the application of CS-cine requires high-quality randomized control trials concerning associations between CS-cine sourced LV parameters and long-term outcomes.
Different CS-cine sequence parameters, cardiac scanning plans, MRI machines, and image analysis software were used in the included studies
Did not investigate LV global longitudinal strain
Performance of CS-cine imaging in evaluating right ventricular function is unknown
CMR examinations usually involve other sequences in addition to the cine sequence

Cite This Study

Wang et al. (2026) conducted a meta-analysis in Left ventricular function evaluation (n=1,969). Compressed-sensing (CS) accelerated cine CMR vs. Standard segmented cine (Std-cine) CMR was evaluated on Left ventricular ejection fraction (LVEF) (SMD -0.05, 95% CI -0.11, 0.01, p=0.12). Compressed-sensing accelerated cine imaging did not differ from standard segmented cine imaging in evaluating left ventricular ejection fraction (SMD -0.05).

synapsesocial.com/papers/6a5333754f7abc118adee08c https://doi.org/10.1186/s12880-026-02522-w

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Performance of compressed-sensing cardiac accelerated cine MR in evaluating left ventricular function: a systematic review and meta-analysis

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Main Result

Limitations

Cite This Study

Performance of compressed-sensing cardiac accelerated cine MR in evaluating left ventricular function: a systematic review and meta-analysis

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Main Result

Limitations

Cite This Study

Also Consider

Also Consider