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July 12, 2026American Journal of Nephrology

Kidney and Cardiovascular Outcomes by CKD stage and etiology of CKD: A Randomly Selected Nationwide Prospective Multicenter Cohort Study in Japan (Reach-J Study)

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Authors

RTRyoya TsunodaTOTomohiro OhigashiJHJunichi Hoshino

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Overview

Randomized trial examines kidney disease impacts on cardiovascular outcomes in Japan, suggesting implications for health management.

Key Points

  • This study aims to identify primary diseases leading to end-stage kidney disease and evaluate their impact on kidney and cardiovascular outcomes.
  • Established the REACH-J cohort with a random sampling method from 31 medical institutions.
  • Enrolled patients with CKD stage G3b–G5 and collected survey data on lifestyle and medical visits.
  • Provided patient medical history with a 5-year follow-up and monitored event rates.
  • Among 2,249 patients, DKD had the highest kidney replacement therapy (KRT) initiation rate in stage G3b.
  • Mortality rate was highest in DKD stage G3b (3.0 per 100 person-years); PKD had the highest KRT initiation in G4/G5.
  • Higher proteinuria predicted poorer renal outcomes; cardiovascular rates did not differ by proteinuria stage.

Cite This Study

Tsunoda et al. (2026) studied this question.

synapsesocial.com/papers/6a5333754f7abc118adee155https://doi.org/10.1159/000553499
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Also Consider

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  1. 1Baseline characteristics and prevalence of cardiovascular disease in newly visiting or referred chronic kidney disease patients to nephrology centers in Japan: a prospective cohort study2013 · 38 citations
  2. 2Longitudinal Follow-Up and Outcomes for Chinese Patients with Stage 1–4 Chronic Kidney Disease2021 · 7 citations
  3. 3#1185 Cardiovascular, renal and mortality risk by the KDIGO risk classification: the first observational study in Japan2024
  4. 4#2755 NURTuRE-CKD: outcomes by primary renal diagnosis2024
  5. 5Five‐Year Outcomes of Chronic Kidney Disease in a Longitudinal Population‐Based Cohort in Western Australia2026