Statistical approaches to make cardiac biomarkers compatible for efficient management of cardiovascular diseases in a regional medical care system

Figures

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  Figure 1. Four quadrants of the two-dimensional plots with various cutoffs. Two-dimensional plots of BNP or NT-proBNP levels (x-axis) against cTnI levels (y-axis) separated by horizontal and vertical cutoff values. The cutoff value for the cTnI level, shown as a horizontal red line, was 26.2 pg/mL. The cutoff values for the BNP level were 40 (A) and 100 pg/mL (D), while those for the NT-proBNP level were 125 (B), 220 (C), 400 (E), and 673 pg/mL (F) (vertical red lines). BNP: B-type natriuretic peptide; NT-proBNP: N-terminal pro-B-type natriuretic peptide; cTnI: cardiac troponin I.

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  Figure 2. Assessment of conformity between BNP and NT-proBNP levels. Two-dimensional plots of BNP and NT-proBNP levels (A and B) with two cutoff values for the NT-proBNP level (horizontal red lines): 400 pg/mL (A) and 673 pg/mL (B). Two-dimensional plots of the BNP level and the eBNP #1 or eBNP #2 values calculated from the NT-proBNP level using formula #1 (C) or formula #2 (D). The cutoff values for BNP (vertical red lines) and eBNP (horizontal red lines) were 100 pg/mL (A–D). BNP: B-type natriuretic peptide; NT-proBNP: N-terminal pro-B-type natriuretic peptide.