Higher mean sensor glucose increased the odds of peroneal motor conduction velocity decline (OR 1.13; p=0.025), and longer diabetes duration predicted sensory nerve action potential deterioration.
Cohort (n=207)
In youth with type 1 diabetes, sustained suboptimal glycemic control and longer disease duration are associated with early electrophysiological abnormalities in peripheral nerves.
Odds Ratio: 1.13
p-value: p=0.025
Abstract Aims We aimed to describe nerve conduction study (NCS) findings in a pediatric type 1 diabetes cohort and to identify clinical and continuous glucose monitoring (CGM) predictors. Methods In this longitudinal study, 207 children and adolescents with type 1 diabetes (mean age 14.0 ± 3.5 years; diabetes duration 6.5 ± 3.5 years) underwent standardised lower‐limb NCS assessing peroneal motor conduction velocity (MCV) and compound muscle action potential (CMAP), and sural sensory conduction velocity (SCV) and sensory nerve action potential (SNAP). Multivariable generalised linear models evaluated associations between nerve conduction parameters and clinical and glycemic variables, including long‐term glycated hemoglobin (HbA1c) and CGM metrics. In 96 participants with paired examinations over 2 years, logistic regression identified predictors of within‐patient deterioration. Results Older age was independently associated with lower peroneal MCV ( B = −0.59; p = 0.001). Male sex was associated with higher CMAP values ( B = 2.04; p = 0.030), whereas higher 5‐year mean HbA1c predicted lower CMAP ( B = −3.72; p < 0.001). Longitudinally, higher mean sensor glucose increased the odds of peroneal MCV decline (OR = 1.13; p = 0.025), and longer diabetes duration predicted SNAP deterioration (OR = 1.32; p = 0.021). Conclusions NCS may detect electrophysiological abnormalities consistent with early nerve dysfunction in pediatric type 1 diabetes. Motor parameters may show earlier vulnerability and relate to cumulative glycemic exposure, whereas sensory axonal involvement may be linked to longer disease duration. Youth with sustained suboptimal glycemic control should be considered at higher risk for early nerve dysfunction. Incorporating NCS into follow‐up may allow timely detection and targeted prevention in this population.
Bombaci et al. (Sat,) conducted a cohort in type 1 diabetes (n=207). Higher mean sensor glucose and longer diabetes duration vs. Lower mean sensor glucose and shorter diabetes duration was evaluated on Peroneal motor conduction velocity (MCV) decline (OR 1.13, p=0.025). Higher mean sensor glucose increased the odds of peroneal motor conduction velocity decline (OR 1.13; p=0.025), and longer diabetes duration predicted sensory nerve action potential deterioration.