Key result
Among adult hypertensive patients, 55.6% experienced at least one drug therapy problem, and the presence of comorbidity significantly increased the odds of having a drug therapy problem (AOR 2.099).
Why the study?
Drug-therapy problems among hypertensive patients can lead to morbidity and mortality, but their occurrence and associated factors required assessment.
Cross-Sectional (n=241)
No
Odds Ratio: 2.099 (95% CI 1.192–3.694)
Absolute Event Rate: 68.7% vs 51.3%
p-value: p=0.010
More than half of adult hypertensive patients in this Ethiopian cohort experienced drug therapy problems, primarily non-adherence, highlighting the need for interventions to improve compliance and manage comorbidities.
Over half of hypertensives had DTPs, mainly non-adherence; leaves open whether pharmacist-led interventions improve adherence in similar settings.
BACKGROUND: Drug-therapy problems(DTPs) among hypertensive patients can result in patient's morbidity and mortality. The main aim of this study was to assess drug therapy problem and associated factors among hypertensive patients. METHODS: A hospital based cross sectional study was conducted. The data was collected from patients' medical charts and through interview. Drug therapy problem was categorized according to Cipolle methods of DTP classification. Thedata was analyzed using the Statistical Package for the Social Sciences (SPSS), version 21. RESULTS: A total of 241 patients were studied. The mean number of antihypertensive medications prescribed were 1.41±0.53. A total of 357 drug therapy problems(DTPs) were identified. From the patients studied,134(55.6%) had at least one evidence of drug therapy problem. Non adherence was the most commonly identified drug therapy problem occurred in (143(59.3%)) patients. Substance use (AOR=0.445, 95% CI= 0.227-0.870, p=0.018) and comorbidity (AOR= 2.099, 95% CI= 1.192-3.694, p=0.010) werethe predictors of DTP. CONCLUSION: More than half of the participants had evidence of onset drug therapy problem. Thus efforts that could boost antihypertensive compliance and minimizes substance use should be adopted to reduce patients's drug therapy problems.
No takes yet. Share an insight, caveat, or question.
Weldegebreal et al. (2019) conducted a cross-sectional in Hypertension (n=241). Comorbidity vs. No comorbidity was evaluated on Presence of drug therapy problem (DTP) (AOR 2.099, 95% CI 1.192-3.694, p=0.010). Among adult hypertensive patients, 55.6% experienced at least one drug therapy problem, and the presence of comorbidity significantly increased the odds of having a drug therapy problem (AOR 2.099).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: