Key result
Right ventricular outflow tract septal pacing resulted in significantly less atrial and ventricular electrical delay and higher left ventricular ejection fraction compared with right ventricular apical pacing (P<0.05).
Why the study?
Does right ventricular outflow tract septal pacing improve electrocardiographic and echocardiographic parameters compared to right ventricular apical pacing in patients with complete atrioventricular block and normal cardiac function?
Cohort (n=80)
Does right ventricular outflow tract septal pacing improve electrocardiographic and echocardiographic parameters compared to right ventricular apical pacing in patients with complete atrioventricular block and normal cardiac function?
p-value: p=<0.05
RVOT septal pacing preserves atrial and ventricular electrical and structural parameters better than RV apical pacing in patients with complete AV block and normal baseline cardiac function.
RVOT septal pacing may better preserve LVEF in AV block; leaves open confirmation before practice change.
BACKGROUND: The effects of right ventricular apical pacing (RVAP) and right ventricular outflow tract (RVOT) septal pacing on atrial and ventricular electrophysiology have not been thoroughly compared. METHODS AND RESULTS: To identify a more favorable pacing strategy with fewer adverse effects, 80 patients who had complete atrioventricular block with normal cardiac function and who were treated with either RVAP (n=42) or RVOT septal pacing (n=38) were recruited after an average of 2 years of follow-up. The data from electrocardiography and echocardiography performed before pacemaker implantation and at the end of follow-up were collected. The patients in the RVOT septal pacing and RVAP groups showed similar demographic and clinical characteristics before pacing treatments. After a mean follow-up of 2 years, the final maximum P-wave duration; P-wave dispersion; Q-, R-, and S-wave complex duration; left atrial volume index; left ventricular end-systolic diameter; ratio of transmitral early diastolic filling velocity to mitral annular early diastolic velocity; and interventricular mechanical delay in the RVOT septal pacing group were significantly less than those in the RVAP group (P<0.05). The final left ventricular ejection fraction of the RVOT septal pacing group was significantly higher than that of the RVAP group (P<0.05). CONCLUSIONS: Compared with RVAP, RVOT septal pacing has fewer adverse effects regarding atrial electrical activity and structure in patients with normal cardiac function.
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Zou et al. (2015) conducted a cohort in Complete atrioventricular block with normal cardiac function (n=80). Right ventricular outflow tract (RVOT) septal pacing vs. Right ventricular apical pacing (RVAP) was evaluated on Atrial and ventricular electrophysiology and echocardiographic parameters (including P-wave duration, QRS duration, LAVI, LVESD, E/e' ratio, interventricular mechanical delay, and LVEF) (p=<0.05). Right ventricular outflow tract septal pacing resulted in significantly less atrial and ventricular electrical delay and higher left ventricular ejection fraction compared with right ventricular apical pacing (P<0.05).
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