Key result
Cigarette smoking in healthy subjects increased blood pressure and catecholamines, but reduced muscle sympathetic nerve activity (-31.8%, P<0.01), suggesting central sympathetic inhibition.
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Smoking inhibits central sympathetic outflow via baroreflex; leaves open peripheral vs central dominance in sustained cardiovascular effects.
Effect estimate: -31.8 +/- 5.1% change
p-value: p=<.01
Grassı et al. (1994) studied normotensive healthy subjects (n=9). Cigarette smoking vs. Sham smoking (control condition) was evaluated on muscle sympathetic nerve activity (-31.8 +/- 5.1% change, p=<.01). Cigarette smoking in healthy subjects increased blood pressure and catecholamines, but reduced muscle sympathetic nerve activity (-31.8%, P<0.01), suggesting central sympathetic inhibition.
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