What question did this study set out to answer?

The aim is to critically assess the EPR effect in human tumors and explore new targeting strategies in cancer nanomedicine.

July 13, 2026Nanomedicine

The EPR effect in human tumors: a critical re-evaluation of a nanomedicine dogma and a call for new targeting paradigms

View Full Paper

Ask AI

Bookmark

The aim is to critically assess the EPR effect in human tumors and explore new targeting strategies in cancer nanomedicine.
Analyzed discrepancies between preclinical and clinical nanoparticle delivery effectiveness.
Investigated alternative targeting mechanisms beyond passive leakage, such as active transcytosis.
Explored advanced strategies like vascular reprogramming and stimuli-responsive nanocarriers.
Preclinical studies show over 5-10% nanoparticle accumulation, while human clinical studies average only 0.7%.
Evidence suggests active mechanisms, like endothelial transcytosis, enhance nanoparticle delivery.
New targeting paradigms could improve patient outcomes and personalization in cancer treatments.

No takes yet. Share an insight, caveat, or question.

Critical re-evaluation of the EPR effect shows potential alternatives for improved cancer treatment targeting.

Dwivedi et al. (2026) studied this question.

View Full Paper

Ask AI

Bookmark