What question did this study set out to answer?

To identify key challenges, scientific gaps, and translation considerations surrounding the enhanced permeability and retention (EPR) effect in nanoparticle-based oncologic drug delivery.

February 20, 2013Cancer Research

Challenges and Key Considerations of the Enhanced Permeability and Retention Effect for Nanomedicine Drug Delivery in Oncology

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Authors

UPUma PrabhakarAstraZeneca (United Kingdom)HMHiroshi MaedaFukuoka Institute of Technology ESEva M. Sevick‐MuracaThe University of Texas MD Anderson Cancer Center

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Implication

Expert consensus report highlights critical limitations of tumor EPR heterogeneity and patient translation, indicating the need to address mechanistic gaps in oncology nanomedicine.

Key Points

To identify key challenges, scientific gaps, and translation considerations surrounding the enhanced permeability and retention (EPR) effect in nanoparticle-based oncologic drug delivery.
Synthesized multidisciplinary expert discussions and perspectives from a dedicated scientific workshop.
Evaluated current preclinical and clinical evidence on tumor vascular permeability, lymphatic clearance, and macromolecule accumulation.
Heterogeneity of the EPR effect across different tumor types and individual patients represents a major barrier to the clinical success of nanomedicine platforms.
Clinical progress is significantly hindered by a scarcity of patient-derived experimental data confirming effective intratumoral drug accumulation mediated by the EPR mechanism.

Cite This Study

Prabhakar et al. (2013) studied this question.

synapsesocial.com/papers/6a7cfeafe7e9b6b0df2fa90f https://doi.org/10.1158/0008-5472.can-12-4561

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Implication

Expert consensus report highlights critical limitations of tumor EPR heterogeneity and patient translation, indicating the need to address mechanistic gaps in oncology nanomedicine.

Challenges and Key Considerations of the Enhanced Permeability and Retention Effect for Nanomedicine Drug Delivery in Oncology

Discussion

Member takes

Implication

Key Points

Cite This Study

Challenges and Key Considerations of the Enhanced Permeability and Retention Effect for Nanomedicine Drug Delivery in Oncology

Discussion

Member takes

Implication

Key Points

Cite This Study

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