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Transport of Engineered Nanoparticles in Solid Tumors: Mechanistic Barriers and Emerging Delivery Strategies

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Review discusses tumor transport challenges of engineered nanoparticles, suggesting strategies for improved delivery.

This review aims to explore the mechanisms affecting the transport of engineered nanoparticles in solid tumors and suggest emerging strategies for their delivery.
Reviewed the factors affecting nanoparticle delivery in tumors.
Examined the enhanced permeability and retention (EPR) and active transport principles.
Discussed tumor barriers and potential stimulus-responsive approaches for better nanoparticle delivery.
Identified significant challenges in nanoparticle transport due to tumor complexity and design variability.
Highlighted the EPR mechanism as crucial for passive nanoparticle entry into tumors.
Proposed new strategies to enhance tumor delivery, integrating both passive and active transport principles.

Singh et al. (2026) studied this question.

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