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July 13, 2026Open Access

Metabolic terrain as the keystone: lactate is a stratified, stroma-independent metabolic-immune axis in pancreatic cancer - a multi-omic analysis of 5,132 tumours

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JPJin-Chae Park

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Overview

Multi-omic analysis reveals lactate as a key metabolic-immune axis in pancreatic cancer, suggesting new therapeutic strategies.

Key Points

  • This study aims to clarify the role of lactate in the metabolic and immune landscape of pancreatic cancer, specifically its independence from desmoplasia.
  • Analyzed bulk transcriptomes and survival from TCGA (n=5,132) and CPTAC-PAAD cohorts (n=134).
  • Conducted single-cell RNA sequencing and spatial transcriptomics in pancreatic tumors.
  • Used Spearman correlation and Cox proportional hazards models to assess lactate's prognostic role.
  • Lactate signature correlated with adverse outcomes (HR 1.69 and 1.48) in pancreatic cancer cohorts.
  • Lactate's negative impact on immune response was found in immune-cold tumors (Spearman r = −0.30).
  • The lactate effect was independent of desmoplasia, showing a strong correlation with CD8 T cell suppression (r −0.26 to −0.33).

Cite This Study

Jin-Chae Park (2026) studied this question.

synapsesocial.com/papers/6a5482a4475c38bf615a5c40https://doi.org/10.5281/zenodo.21303037
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