June 1, 2001Critical Care Medicine
Angiographic correlates of a positive troponin T test in patients with unstable angina
Key result
A positive cardiac troponin T test in patients with unstable angina pectoris was associated with increased odds of thrombus, reduced TIMI flow, and/or critical stenosis (OR 5.8; p<0.0001).
Why the study?
Does a positive cardiac troponin T test correlate with more severe angiographic findings in patients with unstable angina pectoris?
Population
197 subsequently admitted patients with unstable angina pectoris
Comparison
Positive cardiac troponin T test by rapid… vs Negative cardiac troponin T (cTnT) test
Design
Cohort
Follow-up
12 months
Authors
Discussion
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Member takes
Implication
cTnT may stratify unstable angina risk via angiographic severity; leaves open mechanistic links to treatment response.
Study Design
Type
Cohort (n=197)
Structured PICO
Does a positive cardiac troponin T test correlate with more severe angiographic findings in patients with unstable angina pectoris?
P
Population
197 subsequently admitted patients with unstable angina pectoris who underwent cTnT testing and early angiography, followed for 12 months.
E
Exposure
Positive cardiac troponin T (cTnT) test by rapid bedside assay
C
Comparator
Negative cardiac troponin T (cTnT) test
O
Outcome
Angiographic correlates (critical stenoses of culprit lesions, TIMI flow grades, intracoronary thrombus, left ventricular function)surrogate
Main Result
Odds Ratio: 5.8
p-value: p=<.0001
A positive cTnT test in unstable angina indicates more severe coronary artery disease and poorer left ventricular function, providing an angiographic basis for its prognostic value.
Cite This Study
Frey et al. (2001) conducted a cohort in Unstable angina pectoris (n=197). Positive cardiac troponin T (cTnT) test vs. Negative cTnT test was evaluated on Presence of thrombus, reduced thrombolysis in myocardial infarction flow, and/or critical stenosis (>90%) (OR 5.8, p=<.0001). A positive cardiac troponin T test in patients with unstable angina pectoris was associated with increased odds of thrombus, reduced TIMI flow, and/or critical stenosis (OR 5.8; p<0.0001).