Identification and Predictive Value of Interleukin-6 + Interleukin-10 + and Interleukin-6 − Interleukin-10 + Cytokine Patterns in ST-Elevation Acute Myocardial Infarction
Key result
STEMI patients with simultaneous elevation of IL-6 and IL-10 (IL-6+IL-10+) had an increased risk of systolic dysfunction at discharge and death at 6 months compared with IL-6-IL-10+ patients.
Why the study?
Does the combination of elevated IL-6 and IL-10 levels predict worse clinical outcomes in patients with STEMI?
Population
308 participants, including 109 patients with STEMI in the top IL-6 level, 96 in the bottom IL-6 level, and…
Design
Cohort
Follow-up
6 months
Authors
Discussion
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Member takes
Implication
May identify higher-risk STEMI patients; hypothesis-generating for cytokine profiling and requires prospective validation.
Study Design
Type
Observational (n=308)
Structured PICO
Does the combination of elevated IL-6 and IL-10 levels predict worse clinical outcomes in patients with STEMI?
P
Population
308 participants including 205 STEMI patients (109 with high IL-6 and 96 with low IL-6) and 103 matched controls, followed for up to 6 months.
O
Outcome
Systolic dysfunction at discharge and death at 6 monthshard clinical
Cite This Study
Ammirati et al. (2012) conducted an observational in ST-elevation acute myocardial infarction (STEMI) (n=308). Simultaneous elevation of IL-6 and IL-10 (IL-6+IL-10+ pattern) vs. IL-6-IL-10+ pattern and matched controls was evaluated on Systolic dysfunction at discharge and death at 6 months. STEMI patients with simultaneous elevation of IL-6 and IL-10 (IL-6+IL-10+) had an increased risk of systolic dysfunction at discharge and death at 6 months compared with IL-6-IL-10+ patients.