Key result
Complete revascularization is consistently associated with improved long-term survival and clinical outcomes compared to incomplete revascularization in patients with multivessel coronary disease.
Why the study?
Does complete revascularization improve outcomes compared to incomplete revascularization in patients with multivessel coronary artery disease?
Does complete revascularization improve outcomes compared to incomplete revascularization in patients with multivessel coronary artery disease?
Complete revascularization remains the preferred strategy for multivessel disease, showing a trend toward improved outcomes compared to incomplete revascularization across both CABG and PCI.
Questions necessity of complete revascularization in CABG; leaves open whether reasonable incomplete revascularization may be acceptable in selected patients.
For many years, the concept of "complete revascularization" (CR) was considered an absolute truth in coronary surgery with improved long-term survival and a lower rate of reintervention. This was derived from early publications which showed a survival benefit for patients undergoing coronary artery bypass grafting (CABG) who received CR. Many advances in the field of coronary revascularization have been made in the years that passed since those publications, including more frequent use of percutaneous coronary intervention (PCI) in patients with multivessel disease (MVD). This has led some to question the importance of CR and raise the option of "reasonable incomplete revascularization" (IR) for selected patients. The definition of CR is variable in the literature with the two most common definitions being an anatomical (revascularization of all coronary segments with stenosis and larger than a predefined size) and a functional definition (where revascularization is considered complete if all ischemic and viable territories are reperfused). No randomized control trials have been conducted to compare complete versus IR, and a significant proportion of data is based on post hoc analysis of data from randomized control trials and registries. Multiple studies have proven that CR is achieved more frequently with CABG then with PCI. A review of the available data from the past three to four decades shows a trend toward improved results with CR, regardless of the reperfusion strategy chosen. This should impact the heart team discussion when choosing a revascularization strategy and impact the surgical decision making while preforming CABG. IR can be part of a hybrid revascularization strategy or be reserved for rare cases where the cost of achieving CR much outweighs the benefit.
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Leviner et al. (2018) conducted a review in Multivessel coronary artery disease. Complete revascularization vs. Incomplete revascularization was evaluated. Complete revascularization is consistently associated with improved long-term survival and clinical outcomes compared to incomplete revascularization in patients with multivessel coronary disease.
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