Key result
Complete functional revascularization was associated with increased survival after isolated CABG (HR 0.47; 95% CI 0.226-0.969; p=0.041), whereas other definitions showed no effect on mortality.
Why the study?
Multiple definitions of complete surgical revascularization exist in coronary surgery, but there is no agreement on which definition correlates most with early and late outcomes.
Does complete functional revascularization improve long-term survival in patients undergoing isolated CABG?
Cohort (n=162)
Does complete functional revascularization improve long-term survival in patients undergoing isolated CABG?
Hazard Ratio: 0.47 (95% CI 0.226–0.969)
p-value: p=0.041
Complete functional revascularization, guided by viability assessment, is a significant predictor of increased long-term survival in patients undergoing isolated CABG.
May inform CABG strategy; hypothesis-generating and leaves open randomized confirmation of functional definitions.
BACKGROUND: There are several different definitions of complete revascularization on coronary surgery across the literature. Despite the importance of this definition, there is no agreement on which one has the most impact. The aim of this study was to evaluate which definition of complete surgical revascularization correlates with early and late outcomes. METHODS: All consecutive patients submitted to isolated CABG from 2012 to 2016 with previous myocardial scintigraphy were evaluated. EXCLUSION CRITERIA: emergent procedures and previous cardiac surgery procedures. The population of 162 patients, follow-up complete in 100% patients; median 5.5; IQR: 4.4-6.9 years. Each and all of the 162 patients were classified as complying or not with the four different definitions: numerical, functional, anatomical conditional, and anatomical unconditional. Perioperative outcome: MACCE; long-term outcomes: survival and repeat revascularization. Univariable and multivariable analyses were developed to detect predictors of outcomes. RESULTS: Complete functional revascularization was a predictor of increased survival (HR: 0.47; CI 95: 0.226-0.969; p = .041). No other definitions showed effect on follow-up mortality. Age and cardiac dysfunction increased long-term mortality. The definition of complete revascularization did not have an impact on MACCE or the need for revascularization CONCLUSIONS: A uniformly accepted definition of complete coronary revascularization is lacking. This study raises awareness about the importance of viability guidance for CABG.
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Oliveira et al. (2021) conducted a cohort in Isolated CABG (n=162). Complete functional revascularization vs. Not complying with the definition was evaluated on survival (HR 0.47, 95% CI 0.226-0.969, p=0.041). Complete functional revascularization was associated with increased survival after isolated CABG (HR 0.47; 95% CI 0.226-0.969; p=0.041), whereas other definitions showed no effect on mortality.
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