Key result
Malabaricone C lowers blood pressure and attenuates cardiovascular remodeling in hypertensive rats.
Answers are grounded in this paper and cite their sources.
Demonstrates anti-hypertensive effect of malabaricone C in DOCA-salt rats, suggesting its potential as a natural treatment for hypertension.
In this study, we studied whether chronic oral administration of the natural antioxidant, malabaricone C (mal C) can reduce blood pressure (BP) and attenuate cardio-vascular remodeling in deoxycorticosterone acetate (DOCA)-salt hypertensive rats. The dose of mal C for its anti-hypertensive action was optimized by measuring the systolic BP (SBP). DOCA-salt rats showed very high SBP, associated with organ hypertrophy, collagen depositions, and inflammatory infiltrations in cardiac and aortic sections, reduced plasma total antioxidant status and NO level, and increased levels of TBARS, PGI2 as well as vasoconstrictors (AVP, Big ET, and ET-1). DOCA-salt also reduced smooth muscle- and endothelium-dependent vascular relaxation in rats. Mal C reversed all these changes of the DOCA-salt rats and improved their vascular reactivity. Mal C exerts anti-hypertensive property in DOCA-salt rats by reducing oxidative stress and organ hypertrophy, and improving endothelial and vascular functions. Given that mal C has appreciable natural abundance and is non-toxic to rodents, further studies would help in establishing its medicinal potential against hypertension.
No takes yet. Share an insight, caveat, or question.
Rathee et al. (2015) studied Hypertension. Malabaricone C vs. Untreated DOCA-salt rats was evaluated on Blood pressure and cardiovascular remodeling. Chronic oral administration of malabaricone C reduced blood pressure, attenuated cardiovascular remodeling, and improved vascular function in DOCA-salt hypertensive rats.
Synapse has enriched 10 related papers. Consider them for comparative context: